To what extent are the legal restrictions on psychedelics also obstacles to running trials with them in major pharmaceutical R&D countries like the US? 

Personally, I find the acronym frustrating because of how foreign all of it is me based on my own experience as a (fairly new — less than two years) EA in the DC area. I like to think I have an okay read on the community here, and the behaviors and beliefs described by "TESCREALism" just do not seem to map reliably onto how people I know actually think and behave, which has led me to believe that Torres' criticisms are mostly bad faith or strawmen. I admittedly don't interact very much with AI safety or what I sort of nebulously consider to be the "San Francisco faction" of EA (faction probably being too strong a word), so maybe all of y'all over there are just a bunch of weirdos (kidding (like 90%))! 

Sorry, that was ambiguous on my part. There's a differentiation between research ethics issues (how trials are run, etc.) and clinical ethics (medical aid in dying, accessing unapproved treatments, how to treat a patient with X complicated issue, etc.). My work focuses on the former, not the latter, so I can't speak much to that. I meant "conservative" in the sense of hesitance to adjust existing norms or systems in research ethics oversight and, for example, a very strong default orientation towards any measures that reduce risk (or seem to reduce risk) for research participants. 

Yes, the studies should not have used disabled children at all, because disabled children cannot meaningfully provide consent and were not absolutely necessary to achieve the studies' aims. They were simply the easiest targets: they could not understand what was being done to them and their parents were coercible through misleading information and promises of better care, which should have been provided regardless. (More generally, I do not believe proxy consent from guardians is acceptable for any research that involves deliberate harm and no prospect of net benefit to children.) 

The conditions of the facility are also materially relevant. If it were true that children inevitably would contract hepatitis, then a human challenge would not be truly necessary. More importantly, though, I am comfortable calling Krugman's behavior evil because he spent 15 years running experiments at an institution that was managed with heinously little regard for its residents and evidently did not feel compelled to raise the issue with the public or authorities. Rather, he saw the immense suffering and neglect as perhaps unfortunate, but ultimately convenient leverage to acquire test subjects.

I strongly agree with this comment. I think it's important to have a theory of mind of why people think like this. As a non-bioethicist, my impression is a lot of if has to do with the history of the field of bioethics itself, which emerged in response to the horrid abuses in medical research. One major overarching goal that is imbued in bioethics training, research, and writing is prevention of medical abuse, which leads to small-c conservative views that tend to favor, wherever possible, protection of human subjects/patients and an aversion to calculations that sound like they might single out the groups that historically bore the brunt of such abuse.

Like, we've all heard of the Tuskegee Syphilis Experiment, but there were a lot more really awful things done in the last century, which have lasting effects to this day. At 1Day, we're working on trying to bring about safe, efficient human challenge studies to realize a hepatitis C vaccine. We've made great progress and it looks like they will begin within the next year! But the last time people did viral hepatitis human challenge studies, they did them on mentally disabled children! Just heinously evil. So I will not be surprised if some on the ethics boards when they review the proposed studies are quite skeptical at first! (Note: this doesn't mean that the current IRB system is optimal, or even anywhere near so; I view it sort of like zoning and building codes: good in theory — I don't want toxic waste dumps built near elementary schools — but the devil is in the details and how protections are operationalized.)

All of which is to say: like others here, I very strongly disagree with many prevalent views in bioethics. But as I've interacted more and more with this field as an outsider, my opinions have evolved from "wow, bioethics/research ethics is populated exclusively with morons" to "this is mostly a bunch of reasonable people whose frame of references are very different". The latter view allows me to engage more productively to try to change some of the more problematic/wrongheaded views when it comes up in my work and has let me learn a lot, too!

As someone who is not a bioethicist but interacts with many through work (though certainly not as many as Leah), I think that this position for many likely derives from a general opposition to treating people differently based on their intrinsic characteristics. In other words, If I know it's bad to be ageist, I might interpret the thought experiment that nudges someone to save a younger life as ageist (I've heard this argument from one person in bioethics before, but, y'know, n=1) and reject the premise of the question. So for that subset of bioethicists it may not be a serious argument in favor of the proposition but rather a strong preference against making moral judgments involving people that touch upon their intrinsic characteristics.

Chiming in to note a tangentially related experience that somewhat lowered my opinion of IHME/GBD, though I'm not a health economist or anything. I interacted with several analysts after requesting information related to IHME's estimates for global hepatitis C burden (which differed substantially from the WHO's). After a meeting and some emails promising to followup, we were ghosted. I have heard from one other organization that they've had a really hard time getting similar information out of IHME as well. This may be more of an organizational/operational problem rather than a methodological one, but it wasn't very confidence-inspiring.

Woops, link fixed (here it is again). That article is part of a dedicated supplement to HCV challenge/CHIM. 

Speaking in my personal capacity, I agree — I'd love for insurance/that sort of compensation to be the norm. That does not happen enough in medical research, challenge or otherwise. 

I can see why an insurance agency would be very wary. Establishing causation of cancer in general is hard. Even if someone were screened and in perfect liver health during the CHIM, that doesn't mean they won't later adopt common habits (e.g. smoking or excessive drinking) that are risk factors for liver cancer. 

Relatedly, another article in Clinical Infectious Diseases reviewed liver cancer risks due to CHIM, concluding that "[a]lthough it is difficult to precisely estimate HCC risk from an HCV CHIM, the data suggest the risk to be very low or negligible." This was based on analysis of three separate cohorts/datasets of people who had previously been infected with hepatitis C in other contexts. Still, the risk cannot be discounted entirely, and there are risks other than liver cancer that our FAQ document discusses, too.

Perhaps a workaround could be to establish some sort of trust that pays out to any former CHIM participant who develops liver cancer not obviously traceable to something like alcohol abuse disorder, and have this fund liquidate its assets after a certain number of decades. That would be very novel, expensive, and probably legally complicated, and I don't think it's been raised before.